tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate

Name: tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1400264-85-8
Cat. No. CS-0048351
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate|CS-0048351

Structure of 1400264-85-8

Size

Price

Quantity

* Please select Quantity before adding items.

Description

tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate features a sterically hindered piperidine core with dual fluorine atoms at the 3-position, enhancing metabolic stability and modulating electronic properties. The hydrate form ensures improved handling and solubility in aqueous-based reaction systems. This bench-stable intermediate integrates readily into diverse synthetic pathways for bioactive molecule construction.

Application

tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated piperidine scaffolds prevalent in bioactive molecules. The difluoro substitution at C3 enhances metabolic stability and modulates electronic properties, while the 4-oxo functionality supports diverse transformations including reductive amination and nucleophilic addition. Bench-stable and readily purified by standard chromatography, it functions effectively in multistep syntheses requiring robust functional group tolerance.

General Information

CAS No. 1400264-85-8
Cat. No. CS-0048351
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇F₂NO₄
Molecular Weight 253.24
Synonym(s) 1-Boc-3,3-difluoropiperidin-4-one Hydrate
SMILES CC(C)(OC(N1CCC(C(F)(C1)F)=O)=O)C.O

Computational Chemistry Data

TPSA 78.11
LogP 1.0069
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

1400264-85-8 sigma1400264-85-8 manufacturer1400264-85-8 price1400264-85-8 structure1400264-85-8 SDSbuy 1400264-85-81400264-85-8 supplier1400264-85-8 uses1400264-85-8 molecular weightprice of 1400264-85-81400264-85-8 chemical name formula of 1400264-85-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate

CAS No. 1400264-85-8

Recommended Products