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Structure of 14027-75-9
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3-Fluoro-5-nitrobenzoic acid features a fluorine atom at the meta position and a nitro group at the para position relative to the carboxylic acid, creating a strongly electron-deficient aromatic ring. This combination enhances reactivity in nucleophilic substitution and coupling reactions. The compound exhibits bench-stable handling characteristics and integrates readily into synthetic pathways requiring polar, activated aryl intermediates.
3-Fluoro-5-nitrobenzoic acid serves as a versatile building block for the synthesis of substituted heterocycles and bioactive molecules. The ortho-fluoro and meta-nitro groups enable directed metalation and selective functionalization, while the carboxylic acid facilitates derivatization via amide, ester, or acyl chloride formation. Its bench-stable crystalline form and compatibility with standard coupling reactions make it well-suited for iterative synthetic strategies in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: