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CS-W001157 4
Total: USD 88.00

5-Hydroxyfuran-2(5H)-one

  • CAS No. 14032-66-7

  • Cat. No. CS-0196767
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Hydroxyfuran-2(5H)-one|CS-0196767

Structure of 14032-66-7

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General Information

  • CAS No. 14032-66-7
  • Cat. No. CS-0196767
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄O₃
  • Molecular Weight 100.07
  • Synonym(s) 2(5H)-Furanone, 5-hydroxy-
  • SMILES C1=CC(=O)OC1O

Description

5-Hydroxyfuran-2(5H)-one is a reactive heterocyclic scaffold featuring a hydroxyl group at the C5 position and a carbonyl at C2, enabling facile functionalization. This electron-deficient furanone integrates readily into synthetic sequences requiring nucleophilic attack or cyclization, particularly in natural product synthesis and medicinal chemistry.

Application

5-Hydroxyfuran-2(5H)-one serves as a versatile scaffold for heterocyclic synthesis, enabling efficient access to bioactive molecules through established functionalization pathways. Its enolizable carbonyl and hydroxyl groups facilitate selective derivatization under mild conditions, while inherent bench stability supports reliable handling in multi-step sequences. Functions as a key building block in the construction of furan-based pharmaceutical intermediates and natural product analogs.

Synthesis

  • Route1
    • null|null
      98-01-1
    • ~97%
    • In-stock
      5-Hydroxyfuran-2(5H)-one|CS-0196767
      14032-66-7

    References

    • Jong, Johannes C. de; Bolhuis, Fre van; Feringa, Ben L. Tetrahedron: Asymmetry, 1991 , vol. 2, # 12 p. 1247 - 1262
  • Route2
    • 1-(Furan-2-yl)pentan-1-ol|CS-1139873
      30478-77-4
    • ~85%
    • In-stock
      5-Hydroxyfuran-2(5H)-one|CS-0196767
      14032-66-7

    References

    • Lee, Gary C. M.; Syage, Elizabeth T.; Harcourt, Dale A.; Holmes, Judy M.; Garst, Michael E. Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7007 - 7014
  • Route3
    • null|null
      60907-91-7
    • ~82%
    • In-stock
      5-Hydroxyfuran-2(5H)-one|CS-0196767
      14032-66-7
    • null|null
      36169-68-3

    References

    • Lee, Gary C. M.; Syage, Elizabeth T.; Harcourt, Dale A.; Holmes, Judy M.; Garst, Michael E. Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7007 - 7014

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.5822
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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