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CS-W001157 4
Total: USD 88.00

3-Bromo-6-methoxyquinoline

  • CAS No. 14036-96-5

  • Cat. No. CS-W021877
  • Purity≥98%
  • MDL No.MFCD09260428

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-methoxyquinoline|CS-W021877

Structure of 14036-96-5

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General Information

  • CAS No. 14036-96-5
  • Cat. No. CS-W021877
  • Purity ≥98%
  • MDL No. MFCD09260428
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈BrNO
  • Molecular Weight 238.08
  • Synonym(s) Quinoline,3-bromo-6-methoxy
  • SMILES COC1=CC=C2N=CC(Br)=CC2=C1

Description

3-Bromo-6-methoxyquinoline features a quinoline core with complementary bromo and methoxy substituents at electron-rich positions, enabling selective cross-coupling reactions. The para-oriented bromine facilitates palladium-catalyzed transformations, while the ortho-methoxy group enhances solubility and modulates electronic properties for synthetic applications in medicinal chemistry and materials science.

Application

3-Bromo-6-methoxyquinoline serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established halogen reactivity. The methoxy group enhances solubility and modulates electronic properties, while the bromine site facilitates reliable functionalization under standard Suzuki, Stille, or Negishi conditions. Bench-stable and readily purified by flash chromatography, it functions efficiently in the construction of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.0059
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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