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Structure of 1416354-40-9
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Methyl 6-chloro-3-(trifluoromethyl)picolinate features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the chloro substituent at C6 enables selective functionalization. This pyridine-based ester integrates readily into synthetic sequences requiring orthogonal reactivity, offering improved solubility and handling under standard conditions.
Methyl 6-chloro-3-(trifluoromethyl)picolinate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the ester functionality allows for selective reduction or hydrolysis. Bench-stable and compatible with diverse reaction conditions, it facilitates efficient access to substituted pyridine scaffolds relevant to agrochemical and pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: