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Structure of 1421372-94-2
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N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine integrates a fluorinated aniline scaffold with a methylindole-pyrimidine core, enabling efficient coupling in kinase inhibitor scaffolds. This electron-deficient pyrimidine moiety facilitates robust conjugation under standard conditions, offering enhanced stability and solubility for medicinal chemistry applications.
N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of biologically active heterocyclic scaffolds. Its pyrimidine core facilitates Suzuki-Miyaura and Buchwald-Hartwig coupling reactions, while the 4-fluoro and nitro substituents offer orthogonal reactivity for downstream functionalization. The 1-methylindole moiety provides a rigid, aromatic platform compatible with diverse synthetic transformations. This compound exhibits bench stability and is amenable to purification via standard chromatographic methods, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: