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CS-W001157 4
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1-Boc-3-(cyanomethyl)pyrrolidine

  • CAS No. 142253-46-1

  • Cat. No. CS-0005401
  • Purity≥95%
  • MDL No.MFCD06738464
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

1-Boc-3-(cyanomethyl)pyrrolidine|CS-0005401

Structure of 142253-46-1

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Description

1-Boc-3-(cyanomethyl)pyrrolidine features a pyrrolidine core bearing both a Boc-protected amine and a cyanomethyl substituent, enabling sequential functionalization in medicinal chemistry. The nitrile group offers a handle for derivatization via hydrolysis or nucleophilic addition, while the Boc moiety ensures stability during synthesis. This bifunctional scaffold supports rapid access to complex heterocyclic architectures under standard conditions.

Application

1-Boc-3-(cyanomethyl)pyrrolidine serves as a versatile building block for the synthesis of pyrrolidine-based scaffolds in medicinal chemistry. The Boc group provides stability and orthogonal protection, while the cyanomethyl functionality enables downstream transformations such as nucleophilic addition, cyclization, or conversion to amide or carboxylic acid derivatives. Its bench-stable nature and compatibility with standard coupling and reduction protocols facilitate efficient access to complex heterocyclic architectures.

General Information

  • CAS No. 142253-46-1
  • Cat. No. CS-0005401
  • Purity ≥95%
  • MDL No. MFCD06738464
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₈N₂O₂
  • Molecular Weight 210.27
  • Synonym(s) Tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate
  • SMILES N#CCC1CN(CC1)C(OC(C)(C)C)=O

Computational Chemistry Data

  • TPSA   53.33
  • LogP   2.15708
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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