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CS-W001157 4
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Dde-Orn(Fmoc)-OH

  • CAS No. 1423017-87-1

  • Cat. No. CS-0137317
  • Purity≥95%
  • MDL No.MFCD06796885

*For research and further manufacturing use only, not for direct human use.

Dde-Orn(Fmoc)-OH|CS-0137317

Structure of 1423017-87-1

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General Information

  • CAS No. 1423017-87-1
  • Cat. No. CS-0137317
  • Purity ≥95%
  • MDL No. MFCD06796885
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₃₄N₂O₆
  • Molecular Weight 518.60
  • Synonym(s) Nα-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-Nδ-Fmoc-L-ornitine
  • SMILES O=C(O)[C@H](CCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)N/C(C)=C4C(CC(C)(C)CC\4=O)=O

Description

Dde-Orn(Fmoc)-OH is a protected ornithine derivative featuring a Dde (1,2-dihydro-2,2-dimethyl-2-phenyl-3H-inden-3-on-1-yl) group at the ε-amino position and a Fmoc (fluorenylmethoxycarbonyl) group at the α-amino terminus. This dual protection enables selective deprotection in peptide synthesis, facilitating the incorporation of ornithine residues with orthogonal handling. The compound exhibits stability under standard bench conditions and compatibility with common coupling protocols.

Application

Dde-Orn(Fmoc)-OH serves as a protected ornithine building block for solid-phase peptide synthesis, enabling selective incorporation of ornithine residues with orthogonal deprotection. The Dde (1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl) group allows chemoselective removal under mild hydrazinolysis conditions, preserving Fmoc protection and facilitating sequential assembly in complex peptide architectures. Its stability during standard coupling and activation steps supports reliable yield and purity in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   121.8
  • LogP   4.5803
  • H_Acceptors   6
  • H_Donors   3
  • Rotatable_Bonds   9

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