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CS-W001157 4
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2-Bromo-3-fluoro-6-hydroxybenzaldehyde

  • CAS No. 1427382-15-7

  • Cat. No. CS-0136066
  • Molecule weight219.01
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-fluoro-6-hydroxybenzaldehyde|CS-0136066

Structure of 1427382-15-7

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General Information

  • CAS No. 1427382-15-7
  • Cat. No. CS-0136066
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFO₂
  • Molecular Weight 219.01
  • Synonym(s) None
  • SMILES O=CC1=C(C(F)=CC=C1O)Br

Description

2-Bromo-3-fluoro-6-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by bromo and fluoro substituents, enabling direct functionalization in cross-coupling reactions. The hydroxyl moiety enhances solubility and facilitates derivatization, while the electron-withdrawing halogens promote reactivity in transition-metal-catalyzed processes. This ortho-substituted scaffold offers high stability under standard bench conditions.

Application

2-Bromo-3-fluoro-6-hydroxybenzaldehyde serves as a versatile building block for the synthesis of bioactive heterocycles and functionalized aromatic scaffolds. Its orthogonal reactivity profile—combining electrophilic bromine, fluorine, hydroxyl, and aldehyde functionalities—enables selective transformations in multi-step sequences. The compound exhibits good bench stability and facilitates efficient coupling reactions, purification via crystallization, and compatibility with standard protecting group strategies in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1063
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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