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CS-W001157 4
Total: USD 88.00

5-Bromo-3-fluoro-2-methylbenzoic acid

  • CAS No. 1427433-28-0

  • Cat. No. CS-0162974
  • Purity≥97%
  • MDL No.MFCD23712083
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-fluoro-2-methylbenzoic acid|CS-0162974

Structure of 1427433-28-0

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Description

5-Bromo-3-fluoro-2-methylbenzoic acid features a trifunctional aromatic core with bromine, fluorine, and methyl groups positioned for selective functionalization. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The carboxylic acid group provides polarity and facilitates derivatization under standard conditions.

Application

5-Bromo-3-fluoro-2-methylbenzoic acid serves as a versatile building block for the synthesis of substituted aromatic compounds, enabling direct functionalization in late-stage diversification. Its orthogonal halogen and methyl groups facilitate selective cross-coupling reactions, while the carboxylic acid group supports derivatization via amide formation or esterification. The molecule exhibits good bench stability and is compatible with standard purification methods, making it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 1427433-28-0
  • Cat. No. CS-0162974
  • Purity ≥97%
  • MDL No. MFCD23712083
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO₂
  • Molecular Weight 233.04
  • Synonym(s) None
  • SMILES O=C(O)C1=CC(Br)=CC(F)=C1C

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.59482
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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