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CS-W001157 4
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6-Bromo-2-fluoro-3-iodobenzaldehyde

  • CAS No. 1428234-59-6

  • Cat. No. CS-0146401
  • Purity≥97%
  • MDL No.MFCD23713164

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-fluoro-3-iodobenzaldehyde|CS-0146401

Structure of 1428234-59-6

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General Information

  • CAS No. 1428234-59-6
  • Cat. No. CS-0146401
  • Purity ≥97%
  • MDL No. MFCD23713164
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrFIO
  • Molecular Weight 328.90
  • Synonym(s) None
  • SMILES BrC(C=C1)=C(C=O)C(F)=C1I

Description

6-Bromo-2-fluoro-3-iodobenzaldehyde features a trifunctional aryl scaffold with bromo, fluoro, and iodo substituents positioned for orthogonal reactivity. This electron-deficient aldehyde integrates readily into cross-coupling cascades and serves as a high-purity building block for complex heterocycles and functionalized pharmaceutical intermediates under standard conditions.

Application

6-Bromo-2-fluoro-3-iodobenzaldehyde serves as a versatile multi-heteroatom-substituted aryl building block for transition-metal-catalyzed cross-coupling reactions. The ortho-fluoro and para-bromo substituents enable sequential functionalization via palladium-catalyzed coupling, while the iodo group provides high reactivity in Suzuki, Stille, or Negishi reactions. Its bench-stable aldehyde functionality allows direct use in condensation reactions or further derivatization, offering predictable regioselectivity and compatibility with diverse protecting groups and reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.0053
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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