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CS-W001157 4
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4-Bromo-5-(trifluoromethyl)-1H-indazole

  • CAS No. 1428234-73-4

  • Cat. No. CS-0040203
  • Molecule weight265.03
  • Purity≥98%
  • MDL No.MFCD23713147

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-(trifluoromethyl)-1H-indazole|CS-0040203

Structure of 1428234-73-4

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General Information

  • CAS No. 1428234-73-4
  • Cat. No. CS-0040203
  • Purity ≥98%
  • MDL No. MFCD23713147
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrF₃N₂
  • Molecular Weight 265.03
  • Synonym(s) 4-Bromo-5-(trifluoromethyl)indazole
  • SMILES FC(C1=C(Br)C2=C(NN=C2)C=C1)(F)F

Description

4-Bromo-5-(trifluoromethyl)-1H-indazole features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the bromine substituent enables facile cross-coupling reactions. This combination facilitates efficient integration into complex molecular architectures in medicinal chemistry and materials science applications.

Application

4-Bromo-5-(trifluoromethyl)-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the indazole core provides a rigid, bioisosteric scaffold for target engagement. Its bench-stable nature and compatibility with standard coupling conditions facilitate efficient synthesis of complex heterocyclic architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   3.3442
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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