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CS-W001157 4
Total: USD 88.00

4-Bromo-2-(methylsulfonyl)benzoic acid

  • CAS No. 142994-02-3

  • Cat. No. CS-0067989
  • Purity≥98%
  • MDL No.MFCD04037926
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-(methylsulfonyl)benzoic acid|CS-0067989

Structure of 142994-02-3

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Description

4-Bromo-2-(methylsulfonyl)benzoic acid features a bromine atom at the para position relative to the carboxylic acid, paired with a sterically hindered methylsulfonyl group ortho to the acid. This combination imparts enhanced metabolic stability and solubility under standard conditions. The molecule integrates readily into coupling reactions and serves as a key building block for bioactive molecules in medicinal chemistry.

Application

4-Bromo-2-(methylsulfonyl)benzoic acid serves as a versatile building block in medicinal chemistry and process development, enabling direct incorporation into biaryl scaffolds via palladium-catalyzed cross-coupling reactions. The carboxylic acid group facilitates derivatization through amide, ester, or acyl chloride formation, while the bromo and methylsulfonyl functionalities provide orthogonal handles for further functionalization. Its bench-stable solid form and high purity support reliable handling and reproducible synthesis in multi-step routes.

General Information

  • CAS No. 142994-02-3
  • Cat. No. CS-0067989
  • Purity ≥98%
  • MDL No. MFCD04037926
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrO₄S
  • Molecular Weight 279.11
  • Synonym(s) 5-Bromo-2-carboxyphenyl methyl sulphone
  • SMILES O=C(O)C1=CC=C(Br)C=C1S(=O)(C)=O

Computational Chemistry Data

  • TPSA   71.44
  • LogP   1.5508
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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