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CS-W001157 4
Total: USD 88.00

2-Chloro-1-methylpyridinium iodide

  • CAS No. 14338-32-0

  • Cat. No. CS-D1115
  • Purity≥96%
  • MDL No.MFCD00011984

*For research and further manufacturing use only, not for direct human use.

2-Chloro-1-methylpyridinium iodide|CS-D1115

Structure of 14338-32-0

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General Information

  • CAS No. 14338-32-0
  • Cat. No. CS-D1115
  • Purity ≥96%
  • MDL No. MFCD00011984
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClIN
  • Molecular Weight 255.48
  • Synonym(s) 1-Methyl-2-chloropyridinium iodide; 2-Chloro-1-methylpyridinium iodide; N-Methyl-2-chloropyridinium iodide Mukaiyamas
  • SMILES ClC1=[N+](C)C=CC=C1.[I-]

Description

2-Chloro-1-methylpyridinium iodide (Mukaiyama reagent), is a commonly used reagent in organic synthesis for the activation of the hydroxy group of alcohols and carboxylic acids. It is used to synthesize derivatives of esters, lactones, amides, lactams, and ketenes from the corresponding carboxylic acids. It is also used as an efficient coupling reagent in the synthesis of peptides because of its low toxicity, simple reaction conditions, and also less expensive than EDC.2-Chloro-1-methylpyridinium iodide (CMPI) can be used as: A dehydrating agent for the conversion of various aldoximes to nitriles, and alcohols into alkyl thiocyanates. A cross-linking agent to fabricate biodegradable cross-linked hyaluronic acid film and gelatin membranes for biomedical applications. A condensing agent to synthesize various -lactams from -amino acids.

Synthesis

  • Route1
    • null|null
      109-09-1
    • null|null
      74-88-4
    • ~37%
    • In-stock
      2-Chloro-1-methylpyridinium iodide|CS-D1115
      14338-32-0

    References

    • Khoroshilov, Gennadiy; Demchak, Ivan; Saraeva, Tatjana Synthesis, 2008 , # 10 art. no. Z02708SS, p. 1541 - 1544

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.88
  • LogP   -1.8315
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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