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CS-W001157 4
Total: USD 88.00

Fmoc-D-Aph(tBuCbm)-OH

  • CAS No. 1433975-21-3

  • Cat. No. CS-0179056
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Aph(tBuCbm)-OH|CS-0179056

Structure of 1433975-21-3

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Description

Fmoc-D-Aph(tBuCbm)-OH is a sterically hindered, bench-stable amino acid derivative featuring a trifluoromethylated benzyl side chain. This protected D-configured residue integrates efficiently into peptide chains under standard coupling conditions, offering enhanced resistance to metabolic degradation in bioactive sequences.

Application

Fmoc-D-Aph(tBuCbm)-OH serves as a key building block for the synthesis of complex peptide architectures, particularly in the development of macrocyclic and constrained peptides. The D-configured aphthoic acid derivative with orthogonal tBuCbm protection enables selective coupling and late-stage deprotection, facilitating efficient solid-phase peptide synthesis. Its bench-stable Fmoc group and robust tBuCbm deprotection profile support high-purity product formation with minimal side reactions.

General Information

  • CAS No. 1433975-21-3
  • Cat. No. CS-0179056
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₁N₃O₅
  • Molecular Weight 501.57
  • Synonym(s) FMoc-D-4-Aph(tBu-CbM)-OH
  • SMILES CC(C)(C)NC(=O)NC1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)OCC2C3=C(C=CC=C3)C4=C2C=CC=C4

Computational Chemistry Data

  • TPSA   116.76
  • LogP   5.141
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   7

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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