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CS-W001157 4
Total: USD 88.00

Fmoc-D-Aph(tBuCbm)-OH

  • CAS No. 1433975-21-3

  • Cat. No. CS-0179056
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Aph(tBuCbm)-OH|CS-0179056

Structure of 1433975-21-3

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General Information

  • CAS No. 1433975-21-3
  • Cat. No. CS-0179056
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₁N₃O₅
  • Molecular Weight 501.57
  • Synonym(s) FMoc-D-4-Aph(tBu-CbM)-OH
  • SMILES CC(C)(C)NC(=O)NC1=CC=C(C=C1)C[C@H](C(=O)O)NC(=O)OCC2C3=C(C=CC=C3)C4=C2C=CC=C4

Description

Fmoc-D-Aph(tBuCbm)-OH is a sterically hindered, bench-stable amino acid derivative featuring a trifluoromethylated benzyl side chain. This protected D-configured residue integrates efficiently into peptide chains under standard coupling conditions, offering enhanced resistance to metabolic degradation in bioactive sequences.

Application

Fmoc-D-Aph(tBuCbm)-OH serves as a key building block for the synthesis of complex peptide architectures, particularly in the development of macrocyclic and constrained peptides. The D-configured aphthoic acid derivative with orthogonal tBuCbm protection enables selective coupling and late-stage deprotection, facilitating efficient solid-phase peptide synthesis. Its bench-stable Fmoc group and robust tBuCbm deprotection profile support high-purity product formation with minimal side reactions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   116.76
  • LogP   5.141
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   7

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