Exatecan Intermediate 6

Name: Exatecan Intermediate 6
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 143655-58-7
Cat. No. CS-0113881
Purity≥98%
MDL No.MFCD31716093

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Description

Exatecan Intermediate 6 features a strategically positioned lactam moiety and electron-deficient aromatic system, enabling direct integration into complex natural product syntheses. This bench-stable derivative supports efficient coupling reactions under standard conditions, offering reliable access to advanced exatecan analogs in medicinal chemistry workflows.

Application

Exatecan Intermediate 6 serves as a key building block in the synthesis of exatecan-based anticancer agents, featuring a substituted indolocarbazole core with defined regiochemistry. It functions as a versatile scaffold for late-stage functionalization, enabling efficient coupling reactions under standard conditions. The intermediate exhibits excellent bench stability and facilitates straightforward purification, supporting scalable synthesis workflows in medicinal chemistry and process development.

General Information

CAS No. 143655-58-7
Cat. No. CS-0113881
Purity ≥98%
MDL No. MFCD31716093
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₄FNO₂
Molecular Weight 235.26
Synonym(s) None
SMILES CC(NC(C=C(F)C(C)=C1CCC2)=C1C2=O)=O

Computational Chemistry Data

TPSA 46.17
LogP 2.61152
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science ADC Related Compound Payload

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

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Exatecan Intermediate 6

CAS No. 143655-58-7

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