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Structure of 144060-99-1
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This thiazole carboxylic acid features a 4-fluorophenyl substituent and a methyl group at the 4-position, enhancing electronic and steric properties. The carboxylic acid functionality enables direct coupling reactions, while the fluorinated aryl moiety improves metabolic stability and membrane permeability. This scaffold serves as a key building block in medicinal chemistry for targeted kinase inhibitors and bioactive heterocycles.
2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiazole-based scaffolds with enhanced metabolic stability. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions, while the 4-fluorophenyl group provides favorable electronic effects and lipophilicity. The molecule exhibits bench stability and compatibility with standard purification methods, supporting its use in multi-step syntheses and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: