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CS-W001157 4
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Ethyl 4-methyl-2-(3-(trifluoromethyl)phenyl)thiazole-5-carboxylate

  • CAS No. 144061-14-3

  • Cat. No. CS-0313701
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-methyl-2-(3-(trifluoromethyl)phenyl)thiazole-5-carboxylate|CS-0313701

Structure of 144061-14-3

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General Information

  • CAS No. 144061-14-3
  • Cat. No. CS-0313701
  • Purity ≥97%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂F₃NO₂S
  • Molecular Weight 315.31
  • Synonym(s) Ethyl 4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate
  • SMILES CCOC(=O)C1=C(C)N=C(C2=CC(=CC=C2)C(F)(F)F)S1

Synthesis

  • Route1

    References

    • Takeda Pharmaceutical Company Limited Patent: EP2264017 A1, 2010 ; Location in patent: Page/Page column 170 ;
  • Route2

    References

    • Ackermann, Jean; Aebi, Johannes; Binggeli, Alfred; Grether, Uwe; Hirth, Georges; Kuhn, Bernd; Maerki, Hans-Peter; Meyer, Markus; Mohr, Peter; Wright, Matthew Blake Patent: US2005/4187 A1, 2005 ; Location in patent: Page 23 ;
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 4 p. 685 - 695

Safety Information

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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   4.31402
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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