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CS-W001157 4
Total: USD 88.00

8-Bromo-5-chloro-1,2,3,4-tetrahydroisoquinoline

  • CAS No. 1445891-27-9

  • Cat. No. CS-0256963
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Bromo-5-chloro-1,2,3,4-tetrahydroisoquinoline|CS-0256963

Structure of 1445891-27-9

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General Information

  • CAS No. 1445891-27-9
  • Cat. No. CS-0256963
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉BrClN
  • Molecular Weight 246.53
  • Synonym(s) None
  • SMILES ClC1=CC=C(Br)C2=C1CCNC2

Description

8-Bromo-5-chloro-1,2,3,4-tetrahydroisoquinoline features a rigid, electron-deficient tetrahydroisoquinoline core bearing strategically positioned halogen substituents. This combination enables direct functionalization in cross-coupling reactions and provides enhanced metabolic stability for medicinal chemistry applications.

Application

8-Bromo-5-chloro-1,2,3,4-tetrahydroisoquinoline serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its electron-deficient aromatic core enables directed metalation and cross-coupling reactions, while the bromo and chloro substituents offer orthogonal reactivity for sequential functionalization. Bench-stable and amenable to purification by standard chromatography, it facilitates the synthesis of complex isoquinoline-based scaffolds relevant to kinase inhibitors and CNS-targeted compounds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.7482
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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