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Structure of 1448190-10-0
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This hydroxythiazolebenzonitrile integrates a para-cyano group and a methylthiazole moiety, delivering enhanced electron-withdrawing character. The ortho-hydroxyl enables intramolecular hydrogen bonding, stabilizing the enol tautomer and improving solubility in polar solvents. This combination enhances utility in synthetic intermediates for bioactive molecule construction.
2-Hydroxy-4-(4-methylthiazol-5-yl)benzonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its ortho-hydroxynitrile motif offers compatibility with standard coupling reactions and facilitates metal-catalyzed transformations. The thiazole ring imparts enhanced metabolic stability and functional group tolerance, supporting efficient derivatization for lead optimization campaigns. Bench-stable and amenable to purification via flash chromatography or recrystallization, it functions effectively in multistep synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: