(2-Chlorothiazol-5-yl)methanol

Name: (2-Chlorothiazol-5-yl)methanol
Brand: ChemScene
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CAS No. 145015-15-2
Cat. No. CS-0067979
Purity≥95%
MDL No.MFCD03001277

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(2-Chlorothiazol-5-yl)methanol|CS-0067979

Structure of 145015-15-2

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Description

(2-Chlorothiazol-5-yl)methanol features a chlorinated thiazole core bearing a reactive hydroxymethyl group, enabling direct functionalization in synthetic routes. This bench-stable scaffold integrates readily into bioactive molecule frameworks, particularly where halogenated heterocycles enhance target affinity or metabolic stability.

Application

(2-Chlorothiazol-5-yl)methanol serves as a versatile building block for thiazole-based heterocycles, enabling efficient functionalization at the 5-position. Its benzylic-like alcohol functionality facilitates oxidation to the aldehyde or ester, and it participates reliably in coupling reactions with amines, nucleophiles, and transition metal catalysts. The chloro substituent provides orthogonal reactivity for palladium-catalyzed cross-coupling, supporting modular synthesis of bioactive scaffolds. Bench-stable and amenable to standard purification methods, it functions effectively in medicinal chemistry and process development workflows.

General Information

CAS No. 145015-15-2
Cat. No. CS-0067979
Purity ≥95%
MDL No. MFCD03001277
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₄ClNOS
Molecular Weight 149.60
Synonym(s) (2-Chloro-1,3-thiazol-5-yl)methanol
SMILES OCC1=CN=C(Cl)S1

Computational Chemistry Data

TPSA 33.12
LogP 1.2888
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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(2-Chlorothiazol-5-yl)methanol

CAS No. 145015-15-2

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