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CS-W001157 4
Total: USD 88.00

N-9-Fluorenylmethoxycarbonylaspartic acid β-methyl ester

  • CAS No. 145038-53-5

  • Cat. No. CS-0019420
  • Purity≥98%
  • MDL No.MFCD08458573
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

N-9-Fluorenylmethoxycarbonylaspartic acid β-methyl ester|CS-0019420

Structure of 145038-53-5

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Description

N-9-Fluorenylmethoxycarbonylaspartic acid β-methyl ester features a fluorenylmethoxycarbonyl (Fmoc) group for orthogonal protection in peptide synthesis, paired with a β-methyl ester that enhances metabolic stability. This derivative enables efficient incorporation of aspartic acid analogs into complex sequences under standard coupling conditions, offering improved solubility and reduced side reactions during chain elongation.

Application

N-9-Fluorenylmethoxycarbonylaspartic acid β-methyl ester serves as a robust diacid building block for peptide synthesis, enabling selective protection of both α- and β-carboxyl groups. Its fluorenylmethoxycarbonyl (Fmoc) group ensures orthogonal deprotection under mild basic conditions, while the β-methyl ester enhances metabolic stability and modulates steric profile. The compound exhibits excellent bench stability, simplifies purification, and functions reliably in standard solid-phase and solution-phase workflows.

General Information

  • CAS No. 145038-53-5
  • Cat. No. CS-0019420
  • Purity ≥98%
  • MDL No. MFCD08458573
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₉NO₆
  • Molecular Weight 369.37
  • Synonym(s) None
  • SMILES O=C(OC)C[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Computational Chemistry Data

  • TPSA   101.93
  • LogP   2.5414
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   6

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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