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CS-W001157 4
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Imidazo[1,5-c]pyrimidin-5(6H)-one, 7,8-dihydro-

  • CAS No. 14509-66-1

  • Cat. No. CS-0030458
  • Molecule weight137.14
  • Purity≥98%
  • MDL No.MFCD01443896

*For research and further manufacturing use only, not for direct human use.

Imidazo[1,5-c]pyrimidin-5(6H)-one, 7,8-dihydro-|CS-0030458

Structure of 14509-66-1

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General Information

  • CAS No. 14509-66-1
  • Cat. No. CS-0030458
  • Purity ≥98%
  • MDL No. MFCD01443896
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇N₃O
  • Molecular Weight 137.14
  • Synonym(s) 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
  • SMILES O=C1N2C(CCN1)=CN=C2

Description

7,8-Dihydro-Imidazo[1,5-c]pyrimidin-5(6H)-one delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry applications. This bench-stable core integrates readily into bioactive molecules, offering enhanced solubility and metabolic stability in drug discovery workflows.

Application

7,8-Dihydro-imidazo[1,5-c]pyrimidin-5(6H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to bioactive compounds through established coupling and functionalization protocols. Its stable core exhibits favorable solubility and bench stability, facilitating straightforward purification and integration into complex molecular architectures. Functions effectively as a key building block for targeted synthesis of kinase inhibitors and other pharmacologically relevant frameworks.

Synthesis

  • Route1
    • In-stock
      Histamine|CS-4697
      51-45-6
    • null|null
      530-62-1
    • ~87%
    • In-stock
      Imidazo[1,5-c]pyrimidin-5(6H)-one, 7,8-dihydro-|CS-0030458
      14509-66-1

    References

    • Maier, Udo; Grauert, Matthias; Hoffmann, Matthias; Hoenke, Christoph; Joergensen, Anne T.; Pautsch, Alexander; Brandl, Trixi; Breitfelder, Steffen; Scheuerer, Stefan; Erb, Klaus; Pieper, Michael; Pragst, Ingo Patent: US2007/259855 A1, 2007 ; Location in patent: Page/Page column 20 ;
  • Route2
    • In-stock
      Histamine dihydrochloride|CS-W020699
      56-92-8
    • null|null
      530-62-1
    • ~68%
    • In-stock
      Imidazo[1,5-c]pyrimidin-5(6H)-one, 7,8-dihydro-|CS-0030458
      14509-66-1

    References

    • El-Naggar, Mohamed; Piggott, Andrew M.; Capon, Robert J. Organic Letters, 2008 , vol. 10, # 19 p. 4247 - 4250
  • Route3
    • Imidazole Ondansetron Impurity|CS-0229601
      288-32-4
    • In-stock
      1-Methylhistamine dihydrochloride|CS-0046885
      6481-48-7
    • null|null
      530-62-1
    • ~%
    • In-stock
      Imidazo[1,5-c]pyrimidin-5(6H)-one, 7,8-dihydro-|CS-0030458
      14509-66-1

    References

    • WO2007/9757 A1, ; Page/Page column 39 ; WO 2007/009757 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.92
  • LogP   -0.0031
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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