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Structure of 14527-41-4
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Thiazole-5-carboxylic acid integrates a polar carboxylate group at the C5 position of the thiazole ring, enhancing solubility and enabling direct coupling reactions. This scaffold serves as a key building block in medicinal chemistry, where its electron-deficient heterocycle supports target engagement in kinase inhibitors and other bioactive molecules.
Thiazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to bioactive scaffolds. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions under standard conditions. The thiazole ring provides structural rigidity and favorable pharmacophoric properties, enhancing metabolic stability and target affinity in drug discovery campaigns. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses and is compatible with common protecting group strategies.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: