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CS-W001157 4
Total: USD 88.00

Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

  • CAS No. 1455091-10-7

  • Cat. No. CS-0054527
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate|CS-0054527

Structure of 1455091-10-7

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Description

Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate features a fused heterocyclic core with a phenolic hydroxyl and phenoxy substituent, enabling versatile conjugation in bioactive molecule design. The ester functionality offers tunable reactivity under standard conditions, while the electron-rich isoquinoline scaffold supports efficient coupling reactions. This compound serves as a strategic intermediate for medicinal chemistry applications requiring rigid, planar architectures with enhanced solubility profiles.

Application

Methyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate serves as a versatile building block for isoquinoline-based scaffolds, enabling direct functionalization at the C4 hydroxyl and C7 phenoxy positions. Its methyl ester group facilitates downstream derivatization via hydrolysis or nucleophilic substitution, while the phenoxy moiety provides enhanced solubility and stability under standard synthetic conditions. This compound functions effectively in cross-coupling reactions and heterocycle elaboration, supporting efficient access to biologically relevant isoquinoline architectures in medicinal chemistry and materials science applications.

General Information

  • CAS No. 1455091-10-7
  • Cat. No. CS-0054527
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₃NO₄
  • Molecular Weight 295.29
  • Synonym(s) Roxadustat Impurity 4
  • SMILES O=C(C1=C(O)C2=C(C=N1)C=C(OC3=CC=CC=C3)C=C2)OC

Computational Chemistry Data

  • TPSA   68.65
  • LogP   3.5193
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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