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Structure of 146014-66-6
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Methyl 2-fluoro-6-iodobenzoate is a halogenated aromatic ester featuring complementary fluorine and iodine substituents at ortho and para positions relative to the ester group. This electronic and steric profile enables direct cross-coupling reactions under palladium catalysis, offering streamlined access to functionalized biaryl architectures in medicinal chemistry and materials synthesis.
Methyl 2-fluoro-6-iodobenzoate serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki, Stille, and Negishi reactions due to the orthogonal reactivity of its fluorine and iodine substituents. The methyl ester group provides stability and facilitates downstream transformations. Its bench-stable nature and compatibility with standard catalytic systems make it ideal for constructing complex aryl architectures in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: