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Structure of 1469287-08-8
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1-(Pyridazin-3-yl)cyclopropane-1-carboxylic acid features a rigid cyclopropane scaffold fused to a pyridazinyl ring, delivering enhanced metabolic stability and targeted electronic properties. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns requiring conformational constraint and improved membrane permeability.
1-(Pyridazin-3-yl)cyclopropane-1-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its cyclopropyl carboxylic acid motif offers enhanced metabolic stability and conformational rigidity, while the pyridazinyl group provides a polar, hydrogen-bond-capable site for target engagement. The compound exhibits good bench stability, facilitates straightforward derivatization via amide and ester formation, and demonstrates compatibility with standard coupling reagents, making it well-suited for high-throughput synthesis and lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: