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Structure of 1471259-57-0
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4-Bromo-2-chloro-5-(difluoromethyl)pyridine features a uniquely activated pyridine core with orthogonal halogen handles and a strongly electron-withdrawing difluoromethyl group. This combination enables direct cross-coupling or nucleophilic substitution under mild conditions, streamlining access to complex fluorinated heterocycles in medicinal chemistry and agrochemical synthesis.
4-Bromo-2-chloro-5-(difluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogenation pattern. The difluoromethyl group enhances metabolic stability and modulates electronic properties, while the ortho-halogen substitution supports sequential functionalization. Bench-stable and compatible with standard reaction conditions, it facilitates efficient access to complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: