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CS-W001157 4
Total: USD 88.00

4-Bromo-2-fluoro-6-methoxybenzoic acid

  • CAS No. 1472104-49-6

  • Cat. No. CS-0041461
  • Molecule weight249.03
  • Purity≥98%
  • MDL No.MFCD22570393

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-fluoro-6-methoxybenzoic acid|CS-0041461

Structure of 1472104-49-6

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General Information

  • CAS No. 1472104-49-6
  • Cat. No. CS-0041461
  • Purity ≥98%
  • MDL No. MFCD22570393
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO₃
  • Molecular Weight 249.03
  • Synonym(s) None
  • SMILES O=C(O)C1=C(OC)C=C(Br)C=C1F

Description

This boronic acid derivative features a fluorinated and methoxy-substituted benzene core, enabling selective coupling in palladium-catalyzed cross-coupling reactions. The strategic placement of bromo, fluoro, and methoxy groups enhances reactivity while maintaining stability under standard conditions.

Application

4-Bromo-2-fluoro-6-methoxybenzoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-fluoro and meta-bromo substituents enable selective metal-catalyzed coupling reactions, while the carboxylic acid group facilitates direct derivatization or salt formation. The methoxy group enhances solubility and modulates electronic properties, contributing to favorable handling and purification in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.295
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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