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Structure of 147700-62-7
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(3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine features a rigid, chiral phosphorus heterocycle with five aryl substituents that confer exceptional steric shielding and electronic stability. This configuration enables high enantioselectivity in asymmetric catalysis, particularly in transition-metal-catalyzed cross-coupling reactions. The molecule's bench-stable nature and resistance to moisture facilitate handling under standard laboratory conditions.
(3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine serves as a sterically encumbered, bench-stable phosphine ligand that facilitates cross-coupling reactions under mild conditions. Its rigid, electron-rich scaffold enhances catalyst longevity and enables efficient coupling with aryl halides and pseudohalides, particularly in palladium-catalyzed transformations. The molecule’s high functional group tolerance and ease of purification make it well-suited for iterative synthesis and scale-up applications in pharmaceutical process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: