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CS-W001157 4
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Fmoc-Lys(Pal-Glu-OtBu)-OH

  • CAS No. 1491158-62-3

  • Cat. No. CS-0038825
  • Purity≥98%
  • MDL No.MFCD27952849

*For research and further manufacturing use only, not for direct human use.

Fmoc-Lys(Pal-Glu-OtBu)-OH|CS-0038825

Structure of 1491158-62-3

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General Information

  • CAS No. 1491158-62-3
  • Cat. No. CS-0038825
  • Purity ≥98%
  • MDL No. MFCD27952849
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₆H₆₉N₃O₈
  • Molecular Weight 792.06
  • Synonym(s) None
  • SMILES CCCCCCCCCCCCCCCC(N[C@H](C(OC(C)(C)C)=O)CCC(NCCCC[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C(O)=O)=O)=O

Description

Fmoc-Lys(Pal-Glu-OtBu)-OH features a palmitoyl-modified lysine side chain paired with a glutamic acid spacer and tert-butyl ester protection, enabling site-specific conjugation in peptide synthesis. The Fmoc group ensures efficient N-terminal capping, while the hydrophobic palmitate moiety supports membrane anchoring in bioactive peptide designs.

Application

Fmoc-Lys(Pal-Glu-OtBu)-OH serves as a bifunctional amino acid building block for solid-phase peptide synthesis, enabling the incorporation of palmitic acid and glutamic acid side chains. The Fmoc group provides orthogonal protection for the α-amino function, while the Pal-Glu-OtBu moiety offers a stable, hydrophobic anchor and a derivatizable carboxylate for conjugation or further functionalization. This derivative facilitates efficient synthesis of lipidated peptides with defined site-specific modifications, exhibiting excellent bench stability and compatibility with standard coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   160.13
  • LogP   9.3528
  • H_Acceptors   7
  • H_Donors   4
  • Rotatable_Bonds   28

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