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CS-W001157 4
Total: USD 88.00

Sacubitrilat

  • CAS No. 149709-44-4

  • Cat. No. CS-6593
  • Purity≥98%
  • MDL No.MFCD00921225

*For research and further manufacturing use only, not for direct human use.

Sacubitrilat|CS-6593

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General Information

  • CAS No. 149709-44-4
  • Cat. No. CS-6593
  • Purity ≥98%
  • MDL No. MFCD00921225
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₅NO₅
  • Molecular Weight 383.44
  • Synonym(s) Desethyl Sacubitril; LBQ-657
  • SMILES [H]N(C(CCC(O)=O)=O)[C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@H](C(O)=O)C

Description

Sacubitrilat is a potent, orally bioavailable angiotensin receptor-neprilysin inhibitor that integrates dual-acting pharmacophores to modulate the renin-angiotensin and natriuretic peptide systems. This active metabolite features enhanced stability and targeted tissue distribution, enabling sustained inhibition of neprilysin and blockade of AT1 receptors. Designed for cardiovascular therapeutics, it supports improved hemodynamic profiles in heart failure with reduced ejection fraction.

Application

Sacubitrilat serves as a potent, metabolically stable neprilysin inhibitor scaffold, enabling targeted modulation of natriuretic peptide signaling. Its carboxylic acid functionality facilitates direct interaction with the enzyme’s active site, while its aromatic core provides structural rigidity and favorable pharmacokinetic properties. The compound functions as a key intermediate in the synthesis of angiotensin receptor-neprilysin inhibitor (ARNI) therapeutics, offering consistent reactivity and purification advantages in multi-step organic syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H336-H372
Precautionary Statements : P260-P261-P264-P270-P271-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   103.7
  • LogP   3.3565
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   10

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