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Structure of 149849-92-3
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2-Chloropyrimidine-4-carboxylic acid features a chlorine-substituted pyrimidine core paired with a carboxylic acid group, enabling direct functionalization in heterocyclic synthesis. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and agrochemical frameworks under standard conditions.
2-Chloropyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution. Its chloro group exhibits high reactivity toward amines, thiols, and alkoxides under mild conditions, facilitating rapid diversification of pyrimidine scaffolds. The carboxylic acid functionality supports conjugation, derivatization, or salt formation, enhancing solubility and bioavailability. Bench-stable and readily purified by recrystallization, it functions efficiently in standard coupling protocols and is compatible with common protecting groups.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: