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CS-W001157 4
Total: USD 88.00

4-Difluoromethoxy-3-hydroxybenzaldehyde Roflumilast Impurity

  • CAS No. 151103-08-1

  • Cat. No. CS-0229135
  • Purity≥98%
  • MDL No.MFCD04406687

*For research and further manufacturing use only, not for direct human use.

4-Difluoromethoxy-3-hydroxybenzaldehyde Roflumilast  Impurity|CS-0229135

Structure of 151103-08-1

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General Information

  • CAS No. 151103-08-1
  • Cat. No. CS-0229135
  • Purity ≥98%
  • MDL No. MFCD04406687
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂O₃
  • Molecular Weight 188.13
  • Synonym(s) None
  • SMILES FC(OC1=C(C=C(C=O)C=C1)O)F

Synthesis

  • Route1

    References

    • Armani, Elisabetta; Amari, Gabriele; Rizzi, Andrea; Fanti, Renato De; Ghidini, Eleonora; Capaldi, Carmelida; Carzaniga, Laura; Caruso, Paola; Guala, Matilde; Peretto, Ilaria; La Porta, Elena; Bolzoni, Pier T.; Facchinetti, Fabrizio; Carnini, Chiara; Moretto, Nadia; Patacchini, Riccardo; Bassani, Franco; Cenacchi, Valentina; Volta, Roberta; Amadei, Francesco; Capacchi, Silvia; Delcanale, Maurizio; Puccini, Paola; Catinella, Silvia; Civelli, Maurizio; Villetti, Gino Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 793 - 816
  • Route2

    References

    • RANBAXY LABORATORIES LIMITED Patent: US2010/29728 A1, 2010 ; Location in patent: Page/Page column 9 ;
  • Route3
    • null|null
      773093-32-6
    • ~83%
    • 4-Difluoromethoxy-3-hydroxybenzaldehyde Roflumilast  Impurity|CS-0229135
      151103-08-1

    References

    • Zhejiang Dade Pharmaceutical Group Co., Ltd. Patent: US2008/306027 A1, 2008 ; Location in patent: Page/Page column 8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335-H411
Precautionary Statements : P273-P302+P352-P330

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.8061
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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