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CS-W001157 4
Total: USD 88.00

4-Chloro-2,3-dihydroinden-1-one

  • CAS No. 15115-59-0

  • Cat. No. CS-W008929
  • Molecule weight166.60
  • Purity≥97%
  • MDL No.MFCD08544408

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2,3-dihydroinden-1-one|CS-W008929

Structure of 15115-59-0

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General Information

  • CAS No. 15115-59-0
  • Cat. No. CS-W008929
  • Purity ≥97%
  • MDL No. MFCD08544408
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClO
  • Molecular Weight 166.60
  • Synonym(s) 4-Chloro-1-indanone
  • SMILES O=C1C2=CC=CC(Cl)=C2CC1

Description

4-Chloro-2,3-dihydroinden-1-one is a bench-stable, electron-deficient heterocyclic ketone featuring a fused bicyclic structure with a chlorinated aromatic ring. This compound integrates readily into synthetic sequences requiring reactive carbonyl functionality and halogen handles for downstream coupling. Its defined steric profile supports controlled transformations in medicinal chemistry and materials synthesis.

Application

4-Chloro-2,3-dihydroinden-1-one serves as a versatile building block in medicinal chemistry and synthetic organic synthesis. Its electrophilic carbonyl center enables efficient nucleophilic addition and conjugate addition reactions, while the chlorine substituent provides a handle for palladium-catalyzed cross-coupling transformations. The dihydroindenone scaffold offers structural rigidity and is compatible with a range of functional groups, facilitating the construction of complex heterocyclic systems and bioactive molecular architectures under standard reaction conditions.

Synthesis

  • Route1

    References

    • Lan, Kun; Shan, Zi-Xing Synthetic Communications, 2007 , vol. 37, # 13 p. 2171 - 2177
  • Route2
    • null|null
      201230-82-2
    • null|null
      105273-33-4
    • ~63%
    • In-stock
      4-Chloro-2,3-dihydroinden-1-one|CS-W008929
      15115-59-0

    References

    • Takeuchi, Ryo; Yasue, Hiroyuki Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5386 - 5392
  • Route3
    • null|null
      704-96-1
    • ~%
    • In-stock
      4-Chloro-2,3-dihydroinden-1-one|CS-W008929
      15115-59-0

    References

    • WO2003/99795 A1, ; Page 119, 120 ; WO 03/099795 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4689
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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