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Structure of 151504-81-3
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Methyl 4-fluoro-2-nitrobenzoate features a fluorine atom at the para position and a nitro group at the ortho position relative to the ester, creating a strongly electron-deficient aromatic system. This combination enhances reactivity in nucleophilic aromatic substitution and enables direct functionalization under mild conditions. The compound exhibits excellent stability under standard bench protocols and serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals.
Methyl 4-fluoro-2-nitrobenzoate serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization via the orthogonal reactivity of fluorine and nitro groups. Its stability under standard synthetic conditions facilitates downstream transformations such as nucleophilic aromatic substitution, reduction to amino derivatives, and coupling reactions. The ester functionality supports further derivatization, making it valuable for constructing heterocyclic scaffolds and API intermediates in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: