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CS-W001157 4
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5-Bromo-1-cyclopropyl-1H-pyrazole

  • CAS No. 1517978-30-1

  • Cat. No. CS-0377578
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1-cyclopropyl-1H-pyrazole|CS-0377578

Structure of 1517978-30-1

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Description

5-Bromo-1-cyclopropyl-1H-pyrazole features a brominated pyrazole core with a cyclopropyl substituent at the 1-position, delivering enhanced metabolic stability and tunable electronic properties. This scaffold integrates readily into bioactive molecules, serving as a key building block for medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators. The cyclopropyl group imparts conformational rigidity, while the bromine enables facile cross-coupling functionalization under standard conditions.

Application

5-Bromo-1-cyclopropyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality. The cyclopropyl group enhances metabolic stability and modulates lipophilicity, while the pyrazole core provides a rigid, hydrogen-bond-capable scaffold. This compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard Suzuki, Stille, and Negishi coupling protocols for constructing complex heterocyclic architectures.

General Information

  • CAS No. 1517978-30-1
  • Cat. No. CS-0377578
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂
  • Molecular Weight 187.04
  • Synonym(s) None
  • SMILES BrC1=CC=NN1C2CC2

Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.9805
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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