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Structure of 1517978-30-1
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5-Bromo-1-cyclopropyl-1H-pyrazole features a brominated pyrazole core with a cyclopropyl substituent at the 1-position, delivering enhanced metabolic stability and tunable electronic properties. This scaffold integrates readily into bioactive molecules, serving as a key building block for medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators. The cyclopropyl group imparts conformational rigidity, while the bromine enables facile cross-coupling functionalization under standard conditions.
5-Bromo-1-cyclopropyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality. The cyclopropyl group enhances metabolic stability and modulates lipophilicity, while the pyrazole core provides a rigid, hydrogen-bond-capable scaffold. This compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard Suzuki, Stille, and Negishi coupling protocols for constructing complex heterocyclic architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: