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2,4-Dihydroxybutanoic acid

  • CAS No. 1518-62-3

  • Cat. No. CS-0059492
  • Molecule weight120.10
  • Purity≥98%
  • MDL No.MFCD24392009

*For research and further manufacturing use only, not for direct human use.

2,4-Dihydroxybutanoic acid|CS-0059492

Structure of 1518-62-3

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General Information

  • CAS No. 1518-62-3
  • Cat. No. CS-0059492
  • Purity ≥98%
  • MDL No. MFCD24392009
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O₄
  • Molecular Weight 120.10
  • Synonym(s) None
  • SMILES O=C(C(CCO)O)O

Description

Elevated in succinic semialdehyde dehydrogenase deficiency, (±)-2,4-dihydroxybutyric acid lithium salt (CAS 1518-62-3) accumulates due to impaired oxidative catabolism and serves as a diagnostic biomarker for this inborn error of metabolism.

Synthesis

  • Route1

    References

    • ADISSEO FRANCE S.A.S.; Henryon, Vivien; Monbrun, Jerome Patent: US2013/204016 A1, 2013 ; Location in patent: Paragraph 0081; 0082; 0092-0105 ;
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    References

    • Dusselier, Michiel; Van Wouwe, Pieter; De Smet, Sanne; De Clercq, Rik; Verbelen, Leander; Van Puyvelde, Peter; Du Prez, Filip E.; Sels, Bert F. ACS Catalysis, 2013 , vol. 3, # 8 p. 1786 - 1800
  • Route3
    • (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal|CS-1185051
      50-99-7
    • ~%
    • 2,4-Dihydroxybutanoic acid|CS-0059492
      1518-62-3

    References

    • Green Journal of the American Chemical Society, 1956 , vol. 78, p. 1894,1895

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   77.76
  • LogP   -1.1857
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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