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Structure of 152537-03-6
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tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate features a strained azetidine core functionalized with a hydroxyl-bearing ethyl side chain, enabling direct incorporation into bioactive scaffolds. The tert-butyl ester group provides stability and facilitates orthogonal deprotection under mild acidic conditions. This compound serves as a key building block in the synthesis of conformationally constrained amines for medicinal chemistry applications.
tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate serves as a versatile building block for the synthesis of bioactive azetidine-containing scaffolds. The molecule combines a stable tert-butyl carbamate protecting group with a pendant hydroxyl functionality, enabling orthogonal derivatization. It facilitates efficient ring expansion and functionalization in medicinal chemistry campaigns, particularly in the construction of heterocyclic cores via nucleophilic substitution or cyclization reactions. Its bench-stable nature and compatibility with standard purification methods make it well-suited for scalable applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: