Bis-PEG6-NHS ester

Name: Bis-PEG6-NHS ester
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1526718-98-8
Cat. No. CS-0107647
Purity≥97%
MDL No.MFCD24539464

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 1526718-98-8

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Description

Bis-PEG6-NHS ester features two PEG6 chains flanking a reactive NHS ester group, enabling efficient conjugation to primary amines under physiological conditions. This bifunctional linker offers enhanced solubility and spacer length for bioconjugation applications, facilitating site-specific labeling of proteins and peptides with minimal steric interference.

Application

Bis-PEG6-NHS ester serves as a versatile, water-soluble crosslinking reagent for protein and biomolecule conjugation. The two NHS ester groups enable efficient coupling to primary amines under physiological conditions, while the PEG6 spacer provides enhanced solubility and reduced non-specific binding. Its stability in aqueous environments and clean reaction profile facilitate straightforward purification and consistent conjugation yields in bioconjugation workflows.

General Information

CAS No. 1526718-98-8
Cat. No. CS-0107647
Purity ≥97%
MDL No. MFCD24539464
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₃₆N₂O₁₄
Molecular Weight 576.55
Synonym(s) None
SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

Computational Chemistry Data

TPSA 182.74
LogP -0.9194
H_Acceptors 14
H_Donors 0
Rotatable_Bonds 23

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Other Classifications

Building Blocks Functional Group PEG

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Life Science Linker Bis-PEG-NHS

Life Science ADC Related Compound Cleavable Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Bis-PEG6-NHS ester

CAS No. 1526718-98-8

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