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CS-W001157 4
Total: USD 88.00

5-Bromo-3-fluoro-2-nitropyridine

  • CAS No. 1532517-95-5

  • Cat. No. CS-0033199
  • Purity≥97%
  • MDL No.MFCD28129784
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-fluoro-2-nitropyridine|CS-0033199

Structure of 1532517-95-5

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Description

5-Bromo-3-fluoro-2-nitropyridine features a trifunctional pyridine core with bromo, fluoro, and nitro groups positioned for orthogonal reactivity. This electron-deficient heterocycle enables direct coupling in cross-coupling protocols and serves as a key intermediate in medicinal chemistry. The molecule exhibits robust stability under standard bench conditions and facilitates selective functionalization in complex synthesis workflows.

Application

5-Bromo-3-fluoro-2-nitropyridine serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization via palladium-catalyzed cross-coupling reactions. The ortho-nitro and halogen substituents provide complementary reactivity for sequential transformations, while the fluorine atom enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard purification protocols, it facilitates efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

General Information

  • CAS No. 1532517-95-5
  • Cat. No. CS-0033199
  • Purity ≥97%
  • MDL No. MFCD28129784
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrFN₂O₂
  • Molecular Weight 220.98
  • Synonym(s) None
  • SMILES FC1=C([N+]([O-])=O)N=CC(Br)=C1

Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.8914
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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