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Structure of 15336-72-8
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4,4'-Bipiperidine is a rigid, electron-rich dipyridyl scaffold featuring two piperidine rings linked at their 4-positions. This structural motif provides enhanced conformational stability and improved solubility in polar solvents compared to related heterocycles. The molecule integrates readily into pharmaceutical intermediates, where its basic nitrogen atoms facilitate salt formation and modulate pharmacokinetic properties. Its well-defined steric profile supports selective binding in target-directed synthesis.
4,4'-Bipiperidine serves as a versatile bis-heterocyclic scaffold in medicinal chemistry, enabling the construction of rigid, multi-donor systems for target engagement. Its robust bench stability and orthogonal reactivity support efficient functionalization at both nitrogen centers, facilitating downstream derivatization in ligand design. The molecule functions effectively as a core building block in the synthesis of bioactive compounds, particularly those requiring extended pharmacophores with controlled conformational flexibility.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: