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CS-W001157 4
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5-Iodonicotinic acid

  • CAS No. 15366-65-1

  • Cat. No. CS-0130294
  • Molecule weight249.01
  • Purity≥95%
  • MDL No.MFCD07437961

*For research and further manufacturing use only, not for direct human use.

5-Iodonicotinic acid|CS-0130294

Structure of 15366-65-1

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General Information

  • CAS No. 15366-65-1
  • Cat. No. CS-0130294
  • Purity ≥95%
  • MDL No. MFCD07437961
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄INO₂
  • Molecular Weight 249.01
  • Synonym(s) 5-IODOPYRIDINE-3-CARBOXYLIC ACID
  • SMILES O=C(C1=CN=CC(I)=C1)O

Description

5-Iodonicotinic acid delivers a versatile iodinated pyridine scaffold for cross-coupling and bioconjugation applications. The carboxylic acid functionality enables direct derivatization, while the para-iodo group facilitates palladium-catalyzed transformations. This bench-stable, moisture-tolerant reagent integrates seamlessly into synthetic workflows requiring orthogonal functional handles.

Application

5-Iodonicotinic acid serves as a versatile building block for the synthesis of iodinated heterocycles and bioactive molecules. Its iodine substituent enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates direct derivatization or conjugation. The compound exhibits good bench stability and compatibility with standard synthetic protocols, enabling efficient access to functionalized nicotinate scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • 5-Bromonicotinic acid Nicergoline Impurity|CS-0492508
      20826-04-4
    • ~61%
    • In-stock
      5-Iodonicotinic acid|CS-0130294
      15366-65-1

    References

    • Lavilla, Rodolfo; Gullon, Francisco; Bosch, Joan European Journal of Organic Chemistry, 1999 , # 2 p. 373 - 378

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3844
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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