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Structure of 1537382-63-0
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This dihydropyrimidine-2,4(1H,3H)-dione features a 4-bromo-2-fluorophenyl substituent at the C1 position, imparting enhanced electron-withdrawing character and improved metabolic stability. The scaffold serves as a key building block in medicinal chemistry, particularly for kinase inhibitor development, due to its favorable conformational rigidity and hydrogen-bonding capacity.
1-(4-Bromo-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione serves as a versatile building block for medicinal chemistry and heterocyclic synthesis. The molecule combines a brominated aryl moiety with a dihydropyrimidinone core, enabling palladium-catalyzed cross-coupling reactions and facilitating the construction of complex pharmaceutical scaffolds. Its bench-stable nature and compatibility with standard functional group transformations support efficient route development in API discovery programs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: