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Structure of 153836-44-3
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This imidazole derivative features a sterically constrained azetidine ring fused to an electron-deficient imidazole core, delivering enhanced metabolic stability and improved membrane permeability. The dihydrochloride salt form ensures excellent aqueous solubility and handling convenience under standard bench conditions.
1-(Azetidin-3-yl)-1H-imidazole dihydrochloride serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling rapid access to bioactive scaffolds through standard amine functionalization and coupling reactions. The azetidine moiety provides enhanced metabolic stability and membrane permeability, while the imidazole nitrogen atoms offer strong coordination capacity and hydrogen-bonding potential. Bench-stable and readily purified by recrystallization, it functions effectively in peptide conjugation, transition-metal-catalyzed transformations, and diversity-oriented synthesis workflows.
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Lot numbers can be found on the outside label of a product: