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CS-W001157 4
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1-(Azetidin-3-yl)-1H-imidazole dihydrochloride

  • CAS No. 153836-44-3

  • Cat. No. CS-W020483
  • Purity≥95%
  • MDL No.MFCD22056235
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

1-(Azetidin-3-yl)-1H-imidazole dihydrochloride|CS-W020483

Structure of 153836-44-3

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Description

This imidazole derivative features a sterically constrained azetidine ring fused to an electron-deficient imidazole core, delivering enhanced metabolic stability and improved membrane permeability. The dihydrochloride salt form ensures excellent aqueous solubility and handling convenience under standard bench conditions.

Application

1-(Azetidin-3-yl)-1H-imidazole dihydrochloride serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling rapid access to bioactive scaffolds through standard amine functionalization and coupling reactions. The azetidine moiety provides enhanced metabolic stability and membrane permeability, while the imidazole nitrogen atoms offer strong coordination capacity and hydrogen-bonding potential. Bench-stable and readily purified by recrystallization, it functions effectively in peptide conjugation, transition-metal-catalyzed transformations, and diversity-oriented synthesis workflows.

General Information

  • CAS No. 153836-44-3
  • Cat. No. CS-W020483
  • Purity ≥95%
  • MDL No. MFCD22056235
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁Cl₂N₃
  • Molecular Weight 196.08
  • Synonym(s) None
  • SMILES [H]Cl.[H]Cl.N1(C2CNC2)C=CN=C1

Computational Chemistry Data

  • TPSA   29.85
  • LogP   0.871
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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Hazard Statements : N/A
Precautionary Statements : N/A

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