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(S)-N-((3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

  • CAS No. 154590-66-6

  • Cat. No. CS-0143178
  • Purity≥98%
  • MDL No.MFCD18089805

*For research and further manufacturing use only, not for direct human use.

(S)-N-((3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide|CS-0143178

Structure of 154590-66-6

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General Information

  • CAS No. 154590-66-6
  • Cat. No. CS-0143178
  • Purity ≥98%
  • MDL No. MFCD18089805
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₁FN₄O₃
  • Molecular Weight 336.36
  • Synonym(s) N-[[(S)-3-[3-Fluoro-4-(piperazin-1-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide
  • SMILES CC(NC[C@H]1CN(C2=CC=C(N3CCNCC3)C(F)=C2)C(O1)=O)=O

Description

This oxazolidinone derivative features a chiral center and a piperazinyl-substituted aryl group, delivering enhanced solubility and metabolic stability. The fluorinated phenyl moiety imparts electron-withdrawing character, while the acetamide linkage enables facile conjugation in synthetic workflows. Designed for medicinal chemistry applications, it serves as a scaffold for bioactive molecule development.

Application

(S)-N-((3-(3-Fluoro-4-(piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to complex heterocyclic scaffolds. Its oxazolidinone core provides excellent stereocontrol and bench stability, while the piperazinyl and fluoroaryl groups offer complementary sites for further functionalization. The acetamide side chain enhances solubility and facilitates purification, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   73.91
  • LogP   0.6966
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   4

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