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Tetrafluoroisophthalic Acid

  • CAS No. 1551-39-9

  • Cat. No. CS-0168189
  • Purity≥98%
  • MDL No.MFCD00042379

*For research and further manufacturing use only, not for direct human use.

Tetrafluoroisophthalic Acid|CS-0168189

Structure of 1551-39-9

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General Information

  • CAS No. 1551-39-9
  • Cat. No. CS-0168189
  • Purity ≥98%
  • MDL No. MFCD00042379
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₂F₄O₄
  • Molecular Weight 238.09
  • Synonym(s) 2,4,5,6-Tetrafluorobenzene-1,3-dicarboxylic acid
  • SMILES O=C(O)C1=C(F)C(F)=C(F)C(C(=O)O)=C1F

Description

Tetrafluoroisophthalic acid features two carboxylic acid groups flanked by fluorine atoms at the para positions of the aromatic ring, delivering enhanced electron-withdrawing character. This configuration supports robust stability and facilitates integration into high-performance polymers and functional materials requiring strong polarity and thermal resilience.

Application

Tetrafluoroisophthalic acid serves as a versatile building block in the synthesis of fluorinated aromatic compounds and functionalized heterocycles. Its ortho-dicarboxylic acid structure enables efficient metal coordination, amidation, and cyclization reactions under standard conditions. The four fluorine substituents enhance metabolic stability and modulate electronic properties, making it valuable for medicinal chemistry and materials science applications. Bench-stable and readily purified by recrystallization, it functions effectively in both small-scale screening and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   1.6394
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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