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CS-W001157 4
Total: USD 88.00

3,3-Difluoropropanoic acid

  • CAS No. 155142-69-1

  • Cat. No. CS-0054587
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,3-Difluoropropanoic acid|CS-0054587

Structure of 155142-69-1

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Description

3,3-Difluoropropanoic acid features a highly polarized carbonyl group flanked by two fluorine atoms, imparting enhanced electrophilicity and metabolic stability. This electron-deficient acyl moiety integrates readily into bioactive scaffolds, enabling efficient derivatization under mild conditions. The molecule exhibits improved lipophilicity and resistance to enzymatic degradation compared to non-fluorinated analogs, making it valuable for medicinal chemistry campaigns targeting membrane-permeable compounds.

Application

3,3-Difluoropropanoic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of metabolically stable trifluoromethyl-like motifs. Its fluorinated alkyl chain enhances lipophilicity and bioavailability while improving resistance to oxidative metabolism. The carboxylic acid functionality facilitates direct derivatization into esters, amides, or acyl chlorides, supporting diverse downstream transformations. Bench-stable and compatible with standard purification protocols, it functions reliably in peptide coupling, heterocycle synthesis, and macrocyclic scaffold construction.

General Information

  • CAS No. 155142-69-1
  • Cat. No. CS-0054587
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₄F₂O₂
  • Molecular Weight 110.06
  • Synonym(s) 3,3-Difluoropropionic acid
  • SMILES OC(=O)CC(F)F

Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.7262
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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