(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid

Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid
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CAS No. 1562432-09-0
Cat. No. CS-0089033
Purity≥98%
MDL No.MFCD09750517

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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid|CS-0089033

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Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid is a chiral building block featuring a fluorenylmethoxycarbonyl (Fmoc) protected amine and a β-ethoxy ester functionality. This configuration enables direct incorporation into peptide synthesis workflows, where the Fmoc group ensures orthogonal protection during chain elongation. The ethoxy side chain enhances solubility in organic solvents and supports efficient coupling under standard conditions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid serves as a valuable chiral building block in peptide synthesis, enabling efficient incorporation of β-alkoxy amino acid motifs. The Fmoc group provides orthogonal protection for primary amines, while the ethoxy-substituted aliphatic side chain offers enhanced solubility and steric definition. This compound exhibits excellent bench stability, facilitates straightforward purification by flash chromatography, and participates reliably in standard coupling protocols across diverse synthetic workflows.

General Information

CAS No. 1562432-09-0
Cat. No. CS-0089033
Purity ≥98%
MDL No. MFCD09750517
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₂₁NO₅
Molecular Weight 355.38
Synonym(s) N-Fmoc-O-ethyl-L-serine
SMILES O=C(O)[C@H](COCC)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Computational Chemistry Data

TPSA 84.86
LogP 3.0148
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 7

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid

CAS No. 1562432-09-0

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